After accounting for the 50:50 AbbVie profit split, the PTRS-adjusted peak sales for ALEC across their lead programs (i.e., programs with or expecting first clinical data this year) is ~$735M. We own, operate and manage a portfolio of properties at the heart of Hawaii’s business, retail and industrial communities. I feel i should be taking this as a sign... any insight on why I should? By Sean Saint Jacques @SSaintj7 Apr 16, 2021, 9:00am EDT Share this story Guru’s Opinion on Alector Inc. [ALEC]: Based on careful and fact-backed analyses by Wall Street experts, the current consensus on the target price for ALEC … Summary: Denali Therapeutics (NASDAQ: DNLI) and Alector (NASDAQ: ALEC) are two high-profile companies taking a new angle on neurodegenerative diseases like Parkinson’s and Alzheimer’s Disease (PD & AD), notoriously tough nuts to crack. Markets When SPAC-Man Chamath Palihapitiya Speaks, Reddit and Wall Street Listen Buy! Don't hesitate to tell us about a ticker we should know about, but read the sidebar rules before you post. Key data to look out for (beyond the usual safety and PK) are impact on neurofilament light (NfL), a biomarker for neurodegeneration, and volumetric MRI (vMRI), a biomarker for brain atrophy. ALEC is the development leader in FTD-GRN: ALEC is in the pole position in FTD-GRN, though a number of competitors are poised to enter the clinic including DNLI and multiple gene therapy players (PASG, PRVL). r/amcstock: The Official AMC Stock Subreddit. In P1 trials, AL001 restored plasma and CSF PGRN levels back to the normal range, a positive signal of drug activity, and reduced plasma NfL by an average of 14%. BUT i had the WILDEST dream the other night that i basically was being told to buy Apple stock and then continued to purchase and made a ton of money in my dream. FTD patients tend to have on average upwards of 5-7x NfL levels compared to healthy controls, so the extent to which a 14% reduction will be correlated with a clinically meaningful slowing of the neurodegenerative process is far from certain. We do not have a business relationship with the companies mentioned in this report. ... selling stock they don’t own in anticipation of profiting by later picking up the shares even cheaper. Compared to the average trading volume of 797.39K shares, ALEC reached a trading volume of 1071194 in the most recent trading day, which is why market watchdogs consider the stock to be active. We are not receiving compensation for this report. Posts about equities, options, forex, futures, analyst upgrades & downgrades, technical and fundamental analysis, and the stock market in general are all welcome. An icon of the amateur trading masses … Along the same lines, we consider ALEC’s large collaboration with AbbVie on their AD programs ($205M upfront for ALEC) a similar positive signal. If Biogen’s aducanumab is rejected, this number could conceivably climb even higher. Additional upside may be driven by AL101 and other earlier-stage programs. Sell! Multiple near-term inflection points in 2020: ALEC is expected to report data in the coming weeks from their P2 trial for lead asset AL001 in FTD patients with GRN and C9orf72 mutations. The strength of the scientific rationale for their lead programs is variable: AL001 increases PGRN by downregulating SORT1, a degradation pathway for PGRN. Alec’s … We assess a probability of technical and regulatory success (PTRS) of ~10% for their AbbVie-partnered AD portfolio (peak sales of ~$10B, 50% of which goes to ALEC). Guru’s Opinion on Alector Inc. [ALEC]: Based on careful and fact-backed analyses by Wall Street experts, the current consensus on the target price for ALEC … ALEC leverages association studies to identify genetic targets and biomarkers for immuno-neurology therapies. Check out our wiki and Discord! We are cautiously excited about a handful of innovative companies including the two highlighted here (we also previously wrote about Passage Bio (NASDAQ: PASG), a gene therapy CNS player we took a position in). With approximately 80,000,000 cigars in our state of the art humidor, we have a little somethin' for everyone. However, we also note that the scientific rationale for AL001, which promotes circulating levels of PGRN by downregulation of the SORT1 degradation pathway, is less clear in the larger FTD-C9orf72 patient population. Alector Inc. [NASDAQ: ALEC] price plunged by -2.41 percent to reach at -$0.27. Alector Inc ALEC WideScreen charts, DMA,SMA,EMA technical analysis, forecast prediction, by indicators ADX,MACD,RSI,CCI NASDAQ stock exchange Alector Inc ALEC Current Price 07 May, 2021 Closed at:16.35 which is -3.65% from previous closing of 16.97 FTD-GRN constitutes 5 - 10% of the 50 - 60 K FTD cases in the U.S., or about 3 - 6 K patients. Key data to look out for (beyond the usual safety and PK) are impact on neurofilament light (NfL), a biomarker for neurodegeneration, and volumetric MRI (vMRI), a biomarker for brain atrophy. How we decide what to stock? TREM2’s role in neurodegeneration is complex, with differing signals suggesting it may be up- or down-regulated at different points in the disease course, which leads us to take a pessimistic view regarding its potential as a drug target in AD. Whether you're into breaking news, sports, TV fan theories, or a never-ending stream of the internet's cutest animals, there's a community on Reddit for you. He compared Alec’s wife with used coasters that have stains and rings all over them. The market cap for ALEC stock reached $1.28 billion, with 74.82 million shares outstanding and 64.82 million shares in the current float. By Priya Anand (Bloomberg) – Reddit said it raised $250m from private investors, riding a wave of attention after users of the social media website drove a stock market frenzy. ALEC is the development leader in FTD-GRN: ALEC is in the pole position in FTD-GRN, though a number of competitors are poised to enter the clinic including DNLI and multiple gene therapy players (PASG, PRVL). In our assessment, we believe that ALEC should be priced between $25 - 30 per share. The stock market is on a wild ride, with individual investors wielding the power of social media. Find the latest Celsius Holdings, Inc. (CELH) stock quote, history, news and other vital information to help you with your stock trading and investing. You can put a stamp on that, son! Alector Inc. shares reached a high of $11.10 and dropped to a low of $10.45 until finishing in the latest session at While we model ~$1.2B in peak sales potential for AL001 (~$550M in FTD-GRN and ~$700M in FTD-C9orf72), we assign the FTD-GRN and FTD-C9orf72 indications a probability of approval of ~15% and ~10% respectively. He is best known as the co-founder and executive chairman of the social news website Reddit along with Steve Huffman and Aaron Swartz. We do not have a business relationship with the companies mentioned in this report. While ALEC has strong peak sales potential, probability of technical and regulatory success is low. if you are in the US and need any gear, don't heistate to call or email us! Return on Equity for this stock declined to -68.46, with Return on Assets sitting at -28.86. still working my way through all the questions & comments, but just wanted to say thank you! The social media site removed the group from the platform and later restored it without explanation, according to Reuters. After accounting for the 50:50 AbbVie profit split, the PTRS-adjusted peak sales for ALEC across their lead programs (i.e., programs with or expecting first clinical data this year) is ~$735M. However, systemic upregulation of PGRN via suppression of SORT1 may present oncogenic risks. Castration-resistant prostate cancer is associated with sortilin loss and overexpressed progranulin: this is the exact pathway that AL001 modulates. AL003 inhibits SIGLEC3, a unique mechanistic approach in AD. Anything sub 70$ seems undervalued now. However, given the number of potential inflection points (and fairly low bar for success given the use of biomarker endpoints in early stage trials and need for therapies) we would not be surprised if the market continues to reward ALEC despite the underlying concerns we have. Alec Schemmel. New comments cannot be posted and votes cannot be cast, More posts from the StockMarket community. We do not own shares of Alector or Denali Therapeutics. In today’s global business headlines: Wall Street investment bank Morgan Stanley yesterday announced its biggest acquisition since the global financial crisis with the $900m purchase of Canadian-headquartered Solium at a 43% premium to the ruling share price. He shared one of the quotes of Mark Twain on his account, that indirectly poked the critics. Earlier this year, Alec's wife Hilaria Baldwin, who was born Hillary Thomas, was at the center of controversy surrounding her cultural background. We assess a probability of technical and regulatory success (PTRS) of ~10% for their AbbVie-partnered AD portfolio (peak sales of ~$10B, 50% of which goes to ALEC). EDIT: wow, cannot believe how much this blew up! Compared to the average trading volume of 797.39K shares, ALEC reached a trading volume of 1071194 in the most recent trading day, which is why market watchdogs consider the stock to be active. FTD patients tend to have on average upwards of 5-7x NfL levels compared to healthy controls, so the extent to which a 14% reduction will be correlated with a clinically meaningful slowing of the neurodegenerative process is far from certain. Alec’s hedge fund manager was right! Daily Chart. The Knicks are rolling, Alec Burks is a beast and a Stock Up, Stock Down that features the Knicks? Considering the specific makeup of their target population (i.e., patients with declining cognitive function and corresponding behavioral issues and confusion), we could foresee maintaining patient compliance being challenging. See what Alec Larson (alec_larson) has discovered on Pinterest, the world's biggest collection of ideas. Additional upside may be driven by AL101 and other earlier-stage programs. We would caution from indexing too heavily on P1/2 biomarker data as a derisking signal for pivotal development: it remains unclear the extent to which efficacy along these biomarkers will correlate with clinically meaningful impacts given the sheer complexity of neurodegeneration and cognitive function/decline. The average equity rating for ALEC stock is currently 1.60, trading closer to a bullish pattern in the stock market. Applying a peak sales multiple of 3.5 - 4x, we forecast a risk-adjusted valuation of $2.8B in 2024 midyear when AL001 is expected to be under regulatory evaluation / near-launch and the AD assets in pivotal trials, against the current market cap of $2.6B. Real-time trade and investing ideas on Amarin Corporation plc AMRN from the largest community of traders and investors. Alec’s hedge fund manager goes to the New York stock exchange and buys 10 shares @ $15 and returns those to the lender. We would expect disproportionate Medicare representation for neurodegeneration (though not so much for FTD-GRN, an earlier-onset disease)- the introduction of step edits on Medicare Part B could feasibly even allow for a step edit through oral agents given the potential cost savings (assuming an oral is lower cost, particularly from a total cost of care perspective). A sum of 1380657 shares traded at recent session while its average daily volume was at 949.96K shares. SO, if you've read any of my other posts, you know I'm a lawyer who used to work on Wall Street (my office was literally on Wall Street! ALEC is entitled to 50% of global profits. We believe this is a generous assessment of their pipeline PTRS and does not fully capture execution risk, competitive dynamics, and underlying clinical uncertainties. ). Shop Alec Monopoly Hoodies and Sweatshirts designed and sold by artists for men, women, and everyone. When it comes to cigars, no one does it bigger or better than CI. ALEC is the development leader in FTD-GRN: ALEC is in the pole position in FTD-GRN, though a number of competitors are poised to enter the clinic including DNLI and multiple gene therapy players (PASG, PRVL). The latest Internet hype is about a thing that doesn't really exist. Tweet! Alector Inc. (NASDAQ:ALEC) operates as a clinical stage biopharmaceutical company. Moreover, ALEC remains well-funded with ~$550M in cash, cash equivalents, and marketable securities. 3307587005 or [email protected] Reddit value hits $6 billion after users fueled a stock frenzy. He is best known as the co-founder and executive chairman of the social news website A sum of 1380657 shares traded at recent session while its average daily volume was at 949.96K shares. Alexander & Baldwin (NYSE: ALEX) is Hawaii’s premier commercial real estate company. Return on Equity for this stock declined to -68.46, with Return on Assets sitting at -28.86. This signals that analyst sentiment is improving and the stock… ALEC will get to take the first shot at helping this high need population. Our back-of-the-envelope directional peak sales estimate for ALEC’s Alzheimer’s franchise is ~$10B (non-risk adjusted). Over the past three months, the Zacks Consensus Estimate for ALEC's full-year earnings has moved 2.46% higher. Year-to-date, Alector Inc. (NASDAQ:ALEC) stock lost 12.7% … Press question mark to learn the rest of the keyboard shortcuts. It was insane for us to go from a low of $73 all the way up to back above that down channel and … Alector Inc. shares reached a high of $11.10 and dropped to a low of $10.45 until finishing in the latest session at FTD-GRN constitutes 5 - 10% of the 50 - 60 K FTD cases in the U.S., or about 3 - 6 K patients. We are not receiving compensation for this report. Along the same lines, we consider ALEC’s large collaboration with AbbVie on their AD programs ($205M upfront for ALEC) a similar positive signal. Alexander & Baldwin (NYSE: ALEX) is Hawaii’s premier commercial real estate company. A look at their pipelines reveals some overlapping targets (progranulin in FTD, TREM2 in AD), reflecting the similar philosophical starting point for these companies. DNLI also takes a genetically-driven approach to target selection, and possesses a proprietary blood-brain barrier (BBB) transport platform. Alector (ALEC) delivered earnings and revenue surprises of -24.07% and -22.62%, respectively, for the quarter ended September 2020. Reddit is home to thousands of communities, endless conversation, and authentic human connection. If Biogen’s aducanumab is rejected, this number could conceivably climb even higher. Alexis Kerry Ohanian (born April 24, 1983) is an American internet entrepreneur and investor. Bullish. A look at their pipelines reveals some overlapping targets (progranulin in FTD, TREM2 in AD), reflecting the similar philosophical starting point for these companies. While we do expect ALEC price movement driven by pipeline advancement in 2020, on a risk-adjusted basis we would not expect ALEC to hold onto these gains in the long run. Castration-resistant prostate cancer is associated with sortilin loss and overexpressed progranulin: this is the exact pathway that AL001 modulates. ALEC does not provide sufficient value at $32.70 with a market cap of ~$2.6B given a 12 month target price of $25 - 30. Well yesterday was a pretty wild ride if you ask me. Partners for Hawaii. 29th January 2021 by Alec Hogg ‘Their collective buying sends prices surging forcing pros to cover their exposure’, says BizNews founder Alec Hogg. Do the numbers hold clues to what lies ahead for the stock? Reddit value hits $6 billion after users fueled a stock frenzy. Terms of the funding, led by Vy Capital, push the company’s valuation to $6bn, a spokeswoman said. In our assessment, we believe that ALEC should be priced between $25 - 30 per share. ALEC is entitled to 50% of global profits. Multiple shots on goal in AD in early-stage clinical trials with first clinical data expected this year: Both AL002 and AL003 target pathways implicated in AD and are in early stages of clinical development, providing ALEC two bites at the apple with P1 proof-of-mechanism data expected in 2020. Press J to jump to the feed. Multiple near-term inflection points in 2020: ALEC is expected to report data in the coming weeks from their P2 trial for lead asset AL001 in FTD patients with GRN and C9orf72 mutations. ... help Reddit App Reddit coins Reddit premium Reddit gifts. While we do expect ALEC price movement driven by pipeline advancement in 2020, on a risk-adjusted basis we would not expect ALEC to hold onto these gains in the long run. We believe this is a generous assessment of their pipeline PTRS and does not fully capture execution risk, competitive dynamics, and underlying clinical uncertainties. Our objective is to provide short and mid term trade ideas, market analysis & commentary for active traders and investors. Using a discount rate of 11 - 13%, this translates to a 12-month price target of $25 - 30, representing ~25% downside over the current price of $32.70. Alec. Clinical relevance of AL001’s demonstrated impact on biomarkers is unclear: The P1 data for AL001 showed a 14% decrease from baseline in NfL plasma levels in the 5 patients available for assessment at 3 months: it is unclear if this is will prove to be clinically meaningful in FTD (for some context, disease-modifying MS therapies appear to reduce NfL by 20 - 40% after several months to years on therapy). Furthermore, we are also generally hesitant about AL002, which targets TREM2 in AD. Press J to jump to the feed. I think we’d all like to BELIEVE that James Dean was gay – or at least bisexual – and that if we were around at the time we’d have a shot with him. Moreover, ALEC remains well-funded with ~$550M in cash, cash equivalents, and marketable securities. While we model ~$1.2B in peak sales potential for AL001 (~$550M in FTD-GRN and ~$700M in FTD-C9orf72), we assign the FTD-GRN and FTD-C9orf72 indications a probability of approval of ~15% and ~10% respectively. When it comes to the capital structure of this company, Alector Inc. [ALEC] has a Total Debt to Total Equity ratio set at 24.67. Extremely strong leadership team and scientific advisory board, large industry partnership, and strong cash position**:** ALEC boasts an experienced leadership team and prestigious scientific advisory board. We are cautiously excited about a handful of innovative companies including the two highlighted here (we also previously wrote about Passage Bio (NASDAQ: PASG), a gene therapy CNS player we took a position in). EXCLUSIVE: In his first major episodic TV project since his Emmy-winning turn in 30 Rock, Alec Baldwin will star in and executive produce an untitled series for Universal Television and HBO. We would caution from indexing too heavily on P1/2 biomarker data as a derisking signal for pivotal development: it remains unclear the extent to which efficacy along these biomarkers will correlate with clinically meaningful impacts given the sheer complexity of neurodegeneration and cognitive function/decline. This article expresses our own opinions, not Alector’s, Denali’s, or any other party’s opinion. However, systemic upregulation of PGRN via suppression of SORT1 may present oncogenic risks. By Priya Anand (Bloomberg) – Reddit said it raised $250m from private investors, riding a wave of attention after users of the social media website drove a stock market frenzy. The market cap for ALEC stock reached $1.28 billion, with 74.82 million shares outstanding and 64.82 million shares in the current float. This article will focus on the case for and against ALEC. Progranulin and its bioactive fragments are noted to be overexpressed in many cancer types. Billy Baldwin is opening up about his teen son's cancer diagnosis. Progranulin and its bioactive fragments are noted to be overexpressed in many cancer types. The average equity rating for ALEC stock is currently 1.60, trading closer to a bullish pattern in the stock market. This signals that analyst sentiment is improving and the stock… Was he or wasn’t he? ALEC does not provide sufficient value at $32.70 with a market cap of ~$2.6B given a 12 month target price of $25 - 30. Early data suggests AL001 efficiently increases PGRN to normal levels, a positive indication of drug activity. However, given the number of potential inflection points (and fairly low bar for success given the use of biomarker endpoints in early stage trials and need for therapies) we would not be surprised if the market continues to reward ALEC despite the underlying concerns we have. Repeated systemic administration of biologics may present implementation barriers in the real-world for patients with neurodegeneration: ALEC’s portfolio consists of antibodies, which may require that patients come to clinics to receive infusions. TREM2’s role in neurodegeneration is complex, with differing signals suggesting it may be up- or down-regulated at different points in the disease course, which leads us to take a pessimistic view regarding its potential as a drug target in AD. The strength of the scientific rationale for their lead programs is variable: AL001 increases PGRN by downregulating SORT1, a degradation pathway for PGRN. AL003 inhibits SIGLEC3, a unique mechanistic approach in AD. Summary: Denali Therapeutics (NASDAQ: DNLI) and Alector (NASDAQ: ALEC) are two high-profile companies taking a new angle on neurodegenerative diseases like Parkinson’s and Alzheimer’s Disease (PD & AD), notoriously tough nuts to crack. Investors received gains in the millions of percentage points, but in real terms (inflation adjusted) they actually lost 94%. In December 2020, a widely shared Twitter thread collected Baldwin's past interviews and TV appearances and claimed that on numerous occasions she had seemed to fabricate her Spanish heritage. ALEC leverages association studies to identify genetic targets and biomarkers for immuno-neurology therapies. Our back-of-the-envelope directional peak sales estimate for ALEC’s Alzheimer’s franchise is ~$10B (non-risk adjusted). C9orf72 variants are estimated to occur in 7 - 12% of FTD cases (4 - 7 K patients). Additionally, P1b data in mild-moderate AD patients is expected for AL002 and AL003 this year, with AL002 expected to move to P2 by EOY (programs partnered with AbbVie). Over the past three months, the Zacks Consensus Estimate for ALEC's full-year earnings has moved 2.46% higher. Ireland Joins Alec Baldwin In Support New comments cannot be posted and votes cannot be cast. Alec Baldwin took to the social media platform, Instagram, to fight off the accusers of his 36-year-old wife. When it comes to the capital structure of this company, Alector Inc. [ALEC] has a Total Debt to Total Equity ratio set at 24.67. He also co-founded the early-stage venture capital firm Initialized Capital, helped launch the travel search website … ALEC is the development leader in FTD-GRN: ... Just look at the Venezuelan stock market during their recent currency collapse. TOPS from the largest community of traders and investors. Partners for Hawaii. Alector Inc. [NASDAQ: ALEC] price plunged by -2.41 percent to reach at -$0.27. Applying a peak sales multiple of 3.5 - 4x, we forecast a risk-adjusted valuation of $2.8B in 2024 midyear when AL001 is expected to be under regulatory evaluation / near-launch and the AD assets in pivotal trials, against the current market cap of $2.6B. While this is no guarantee for success, a company’s ability to get thought leaders to sign on does provide some signal to potential investors that there is scientific and clinical promise. However, we also note that the scientific rationale for AL001, which promotes circulating levels of PGRN by downregulation of the SORT1 degradation pathway, is less clear in the larger FTD-C9orf72 patient population. Stock market news live updates: Wall Street pinned in red with investors spooked by inflation Wall Street was hammered on Wednesday, as fears of rising inflation yanked blue-chip and technology stocks lower, and amplified new concerns about the rebound from COVID-19. While this is no guarantee for success, a company’s ability to get thought leaders to sign on does provide some signal to potential investors that there is scientific and clinical promise. Considering the specific makeup of their target population (i.e., patients with declining cognitive function and corresponding behavioral issues and confusion), we could foresee maintaining patient compliance being challenging. A group called Robinhood Stock Traders lost out to the sheriff — in this case, Facebook. We model approximately ~$1.2B in peak sales potential for AL001 (~$550M in FTD-GRN and ~$700M in FTD-C9orf72). We own, operate and manage a portfolio of properties at the heart of Hawaii’s business, retail and industrial communities. In P1 trials, AL001 restored plasma and CSF PGRN levels back to the normal range, a positive signal of drug activity, and reduced plasma NfL by an average of 14%. Additionally, P1b data in mild-moderate AD patients is expected for AL002 and AL003 this year, with AL002 expected to move to P2 by EOY (programs partnered with AbbVie). Extremely strong leadership team and scientific advisory board, large industry partnership, and strong cash position**:** ALEC boasts an experienced leadership team and prestigious scientific advisory board. Some collectors are spending millions of dollars on these digital items called nonfungible tokens, or NFTs. DNLI also takes a genetically-driven approach to target selection, and possesses a proprietary blood-brain barrier (BBB) transport platform.